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產品(pǐn)編(biān)號 |
英文名(míng)稱 |
CAS號 |
包(bāo)裝(zhuāng) |
|
Y3709 |
Capsaicin |
404-86-4 |
可根據(jù)客(kè)戶要求訂(dìng)製(zhì) |
產品編號：Y3709
英(yīng)文(wén)名(míng)稱：Capsaicin
CAS號：404-86-4
分析(xī)標(biāo)準品,≥95%(HPLC),
分子(zǐ)式(shì) C18H27NO3 分子(zǐ)量(liáng)305.41 密(mì)度 1.041
熔(róng)點 62-65°C
存貯條件(jiàn) 儲存(cún)溫度 2-8°C
基(jī)本(běn)信(xìn)息(xī):
描(miáo)述
別(bié)名 辣椒鹼(jiǎn) ;天(tiān)然辣椒素(sù),(E)-N-(4-羥(qiǎng)基-3-甲(jiǎ)氧(yǎng)基苄基)-8-甲基-6-壬(rén)烯酰(xiān)胺(àn) ;E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
生(shēng)化(huà)機(jī)理(lǐ)
Description:
IC50 Value: 150 M (MTT assay in FaDu cells) [1]
Capsaicin is the active component of chili peppers, which are plantsbelonging to the genus Capsicum. Capsaicin, as a member of the vanilloidfamily, binds to a receptor called the vanilloid receptor subtype 1 (VR1). Capsaicin is able to kill prostate cancer and lung cancer cells by causing them to undergo apoptosis.
in vitro: Treatment of A172 cells withcapsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3. Interestingly, synergistic induction of morphological alternation was observed when A172 cells were treated with capsaicin [2]. After the addition of capsaicin, the levels of reactive oxygen species were reduced slightly in the earlier stage of treatment. Interestingly, an elevation of intracellular calcium ion concentration was detected in the MCF-7 cells [3].
in vivo: Intraperitoneal administration of CAP (10mg/kg body weigh
分析(xī)標(biāo)準品(pǐn),≥95%(HPLC),
分子式 C18H27NO3 分子量(liáng)305.41 密(mì)度(dù) 1.041
熔點 62-65°C
存貯條(tiáo)件(jiàn) 儲(chǔ)存溫度(dù) 2-8°C
描述
別(bié)名(míng) 辣椒鹼 ;天然辣(là)椒(jiāo)素(sù),(E)-N-(4-羥基(jī)-3-甲(jiǎ)氧(yǎng)基(jī)苄基(jī))-8-甲基(jī)-6-壬(rén)烯酰(xiān)胺(àn) ;E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
生(shēng)化機理(lǐ)
Description:
IC50 Value: 150 M (MTT assay in FaDu cells) [1]
Capsaicin is the active component of chili peppers, which are plantsbelonging to the genus Capsicum. Capsaicin, as a member of the vanilloidfamily, binds to a receptor called the vanilloid receptor subtype 1 (VR1). Capsaicin is able to kill prostate cancer and lung cancer cells by causing them to undergo apoptosis.
in vitro: Treatment of A172 cells withcapsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3. Interestingly, synergistic induction of morphological alternation was observed when A172 cells were treated with capsaicin [2]. After the addition of capsaicin, the levels of reactive oxygen species were reduced slightly in the earlier stage of treatment. Interestingly, an elevation of intracellular calcium ion concentration was detected in the MCF-7 cells [3].
in vivo: Intraperitoneal administration of CAP (10mg/kg body weigh
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