產(chǎn)品編(biān)號：Y3696

英(yīng)文名稱(chēng)：Baicalein  

分(fēn)子式 C15H10O5 分子量(liáng)270.24  

基本信息(xī):

敏感性(xìng)   對(duì)光和熱敏(mǐn)感(gǎn)
密度  1.548
熔點(diǎn)   256-271°C
溶(róng)解性(xìng)   Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water
存(cún)貯(zhù)條(tiáo)件(jiàn)   儲(chǔ)存溫(wēn)度2-8℃
描(miáo)述  
產品介(jiè)紹   Baicalein is a cell-permeable flavone, originally isolated from the roots of Scutellaria baicalensis, that inhibits cellular Ca2+ uptake, calcium mobilization, and adjuvant-induced arthritis. Baicalein has been shown to inhibit platelet 5-LO (5-lipoxygenase) (IC50=9.5 mM) and 12-LO (12-lipoxygenases) (IC50=0.12 mM) and reverse transcriptase. Baicalein reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Baicalein is a potent anti-inflammatory and anti-tumor agent, and it blocks PREP (prolyl oligopeptidase). Baicalein induces the S-phase arrest and apoptosis in proliferation of human lung squamous carcinoma CH27 cells. The declining expression of cdk1, cdk2, cyclin D2 and cyclin A by Baicalein resulted in the G1 and G2 cell cycle arrest in C6 rat glioma cells. Baicalein has anti-thrombotic, antiproliferative and anti-mitogenic effects. Baicalein inhibits protein tyrosine kinase in leukemia (CEM) cells and PMA-stimulated PKC (protein kinase C). Baicalein is an inhibitor of 15-LO and CYP2C9.
別名(míng)   三羥黃酮; 黃(huáng)芩(qín)苷元; 黃(huáng)芩黃(huáng)素(sù); 黃芩甙元; 5,6,7-三(sān)羥基(jī)黃(huáng)酮;5,6,7-Trihydroxyflavone
生化機(jī)理   中藥類(lèi)黃酮的組成成分，黃芩的(dí)主要(yào)黃(huáng)酮(tóng)，抑(yì)製花生四烯酸代謝中的(dí)12-脂肪(fáng)氧化酶路徑(jìng)（12-lipoxygenase ，12-LOX），此(cǐ)路徑能抑(yì)製癌(ái)細胞的增殖，誘導凋亡途徑
。
應(yīng)用   An inhibitor of Ca2+ uptake, 5-LO, and 12-LO