英(yīng)文名稱：Genistein  
CAS號(hào)：446-72-0
分析標準(zhǔn)品,≥98%  
分子(zǐ)式(shì) C15H10O5 分子量(liáng)270.24  

基本(běn)信息:

屬性  
密度(dù)  1.548
熔(róng)點(diǎn)   297-298°C
存(cún)貯條(tiáo)件(jiàn)   儲(chǔ)存(cún)溫(wēn)度 -20°C
描述(shù)  
產品介紹   溶於(yú)乙醇(chún)和(hé)DMSO， 幹冷(lěng)處(chǔ)保(bǎo)存。
別(bié)名   金雀異(yì)黃(huáng)酮 ;4',5,7-三(sān)羥基異(yì)黃(huáng)酮,染(rǎn)料木黃酮(tóng), 染料木(mù)素;4',5,7-Trihydroxyisoflavone 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
生(shēng)化機理(lǐ)  
Description:  
IC50 Value: 37.5 uM( Topo II) [3]  
Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK) which blocks the mitogenic effect mediated by EGF on NIH-3T3 cells with IC50 of 12μM or by insulin with IC50 of 19 μM. It has been shown that genistein inhibits many type of cancers including prostate cancer (PCa) by regulating several cell signaling pathways and microRNAs (miRNAs).  
in vitro: GEN effectively reversed estrogenicity of BPA by reversing mRNA and protein expressions of ERα, IGF-1R, pIRS-1, and pAkt induced by BPA in cellular model and also significantly decreased tumor growth and in vivo expressions of ERα, pIRS-1, and pAkt in xenografted mouse model [1]. Interestingly, genistein and its analogs induced caspase 3-activation supporting apoptotic mechanism of cell death but SPG-G supported caspase 3-independent apoptosis [2]. Of the compounds tested, only genistein selectively inhibited human topo II activity and had an IC50 value of 37.5 M [3]  
Clinical trial: Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate Cancer. Phase 2  
應用   1，具有(yǒu)雌性激(jī)素(sù)及(jí)抗雌激素性質(zhì)
2，在(zài)體(tǐ)內(nèi)能(néng)抑製結(jié)腸(cháng)癌，乳(rǔ)腺癌(ái)，皮膚(fū)癌，前(qián)列(liè)腺癌(ái)等(děng)  
3，對(duì)多種(zhǒng)腫瘤細(xì)胞株有(yǒu)抑(yì)製(zhì)作(zuò)用  
4，具有抗氧(yǎng)化作(zuò)用  
5，可(kě)以抑製酪(lào)氨酸蛋白(bái)激(jī)酶（PTK）的活性  
6，可以抑(yì)製(zhì)拓(tuò)撲異購酶(méi)Ⅱ的活性  
7，可以預防絕經(jīng)後骨質(zhì)疏鬆(sōng)  
8，具有誘發(fā)細(xì)胞程(chéng)序性(xìng)死亡，提高抗癌藥效，抑(yì)製血管生成等作用，是(shì)一種(zhǒng)很(hěn)有潛力的(dí)癌症(zhèng)化(huà)學(xué)預(yù)防劑，其抗癌作用及機製具有(yǒu)廣泛的應(yīng)用前(qián)景。