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產(chǎn)品(pǐn)編號 |
英(yīng)文(wén)名(míng)稱(chēng) |
CAS號 |
包(bāo)裝 |
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Y3592 |
Emodin |
518-82-1 |
可根(gēn)據(jù)客戶要(yào)求訂(dìng)製(zhì) |
英文名(míng)稱：Emodin
CAS號(hào)：518-82-1
分析標準品，≥96.0% (HPLC)
分子式 C15H10O5 分子量270.24
基本信息(xī):
密度(dù) 1.583
熔點 256-257°C
存(cún)貯(zhù)條件 儲存(cún)溫(wēn)度 2-8°C
描述(shù)
產品介紹(shào) 溶(róng)於乙(yǐ)醇(chún)，略(lüè)溶(róng)於乙醚，氯仿，苯，不溶(róng)於(yú)水(shuǐ)。溶於苛性(xìng)鹼(jiǎn)水溶液，碳本(běn)酸(suān)鈉(nà)水溶液(yè)，氨(ān)溶液(yè)中(zhōng)顯櫻(yīng)紅(hóng)色。
別名(míng) 大黃(huáng)素(sù) ;朱(zhū)砂蓮(lián)甲素,1,3,8-三(sān)羥基(jī)-6-甲基(jī)蒽(ēn)醌(kūn);1,3,8-Tri-hydroxy-6-methyl-anthra-quinone 6-Methyl-1,3,8-tri-hydroxy-anthra-quinone Emodol Frangula-emodin
生化(huà)機(jī)理
Description:
IC50 Value: observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Emodin exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
in vitro: At 6h after emodin treatment, the levels of GDF15, CYP1A1, CYP1B1, and CYR61 were upregulated [1]. Emodin increased the resting tension of gallbladder smooth muscle strips and inhibited voltage-dependent K(+) current in a dose-dependent manner. When 10 microM emodin was applied to gallbladder smooth muscle cells for 3-6 min., the amplitude of voltage-dependent K(+) current was decreased by 31.5 +/- 0.5% at +40 mV, and this inhibitory effect mostly recovered after washout [2].
Clinical trial: N/A
應(yīng)用 抑(yì)製NF -κB活化(huà)及粘(nián)附分子(zǐ)的(dí)表(biǎo)達。酪(lào)蛋白激(jī)酶2（CK2的(dí)）抑(yì)製劑(jì).
熔點 256-257°C
存(cún)貯(zhù)條件 儲存(cún)溫(wēn)度 2-8°C
描述(shù)
產品介紹(shào) 溶(róng)於乙(yǐ)醇(chún)，略(lüè)溶(róng)於乙醚，氯仿，苯，不溶(róng)於(yú)水(shuǐ)。溶於苛性(xìng)鹼(jiǎn)水溶液，碳本(běn)酸(suān)鈉(nà)水溶液(yè)，氨(ān)溶液(yè)中(zhōng)顯櫻(yīng)紅(hóng)色。
別名(míng) 大黃(huáng)素(sù) ;朱(zhū)砂蓮(lián)甲素,1,3,8-三(sān)羥基(jī)-6-甲基(jī)蒽(ēn)醌(kūn);1,3,8-Tri-hydroxy-6-methyl-anthra-quinone 6-Methyl-1,3,8-tri-hydroxy-anthra-quinone Emodol Frangula-emodin
生化(huà)機(jī)理
Description:
IC50 Value: observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Emodin exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
in vitro: At 6h after emodin treatment, the levels of GDF15, CYP1A1, CYP1B1, and CYR61 were upregulated [1]. Emodin increased the resting tension of gallbladder smooth muscle strips and inhibited voltage-dependent K(+) current in a dose-dependent manner. When 10 microM emodin was applied to gallbladder smooth muscle cells for 3-6 min., the amplitude of voltage-dependent K(+) current was decreased by 31.5 +/- 0.5% at +40 mV, and this inhibitory effect mostly recovered after washout [2].
Clinical trial: N/A
應(yīng)用 抑(yì)製NF -κB活化(huà)及粘(nián)附分子(zǐ)的(dí)表(biǎo)達。酪(lào)蛋白激(jī)酶2（CK2的(dí)）抑(yì)製劑(jì).
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