英文名稱：Evodiamine  
CAS號(hào)：518-17-2
分析標準(zhǔn)品,≥99%  
分子式 C19H17N3O 分(fēn)子量(liáng)303.36  

基本信息(xī):

敏感性(xìng)   對(duì)光敏感
密度(dù)  1.39
熔點   278°C
溶(róng)解(jiě)性(xìng)   Soluble in DMSO (5 mg/mL,warm to 40°C), water (<1 mg/mL) at 25 °C, and ethanol (<1 mg/mL) at 25 °C
存貯(zhù)條件   陰涼幹燥(zào)，避(bì)光保(bǎo)存(cún)
描述(shù)  
產品(pǐn)介紹(shào)   Evodiamine is a quinozole alkaloid isolated from Evodia rutaecarpa, described as an agonist of the VR1 (vanilloid receptor subtype 1, TRPV1) with affinity (Ki = 5.95 microM) comparable to that of the prototypical VR1 chemical activator Capsaicin .Evodiamine induction of 45Ca2+ uptake was competitively antagonized by the Capsaicin antagonist Capsazepine .Evodiamine is described to inhibit prostaglandin E2 synthesis, cyclooxygenase-2 induction and NF-κB activation, producing antiinflammatory effects.
別(bié)名   吳(wú)茱(zhū)萸胺;
生化機理   The interferon-γ priming signal regulating the transcriptional activation of the iNOS gene is blocked by Evodiamine, suppressing iNOS protein synthesis but not affecting iNOS function. Evodiamine also demonstrates antiangiogenesis through inhibition of vascular endothelial growth factor gene expression and inhibition of the ERK 1 (p44)/ERK 2 (p42) mitogen-activated protein kinase that correlated to endothelial cell angiogenesis. Promotion of apoptosis in human leukemic U937 cells is described with Evodiamine.
應用(yòng)   An antiangiogenic and antiinflammatory agonist of TRPV1.