密度1.48
存(cún)貯(zhù)條(tiáo)件 儲(chǔ)存(cún)溫度(dù)2-8°C
描述
產(chǎn)品介紹(shào) 雷(léi)公藤(téng)甲(jiǎ)素(sù)是(shì)一個具(jù)有(yǒu)多種生物活(huó)性(xìng)的二萜內酯，可(kě)溶(róng)於二甲基(jī)亞碸.來源於(yú)中藥雷公(gōng)藤的根
別名 雷(léi)公藤甲素(sù) ;雷公藤內(nèi)酯醇(chún),雷公藤(téng)多甙(dài);PG 490
生化(huà)機理(lǐ)
Triptolide inhibits cytokine-induced gene expression via inhibition of NF-κB transcriptional activity. Triptolide induces apoptosis in tumor cells by blocking TNF-α mediated c-IAP2 and c-IAP1 (members of the inhibitor of apoptosis family) induction. Immunosuppressive with anti-inflammatory and antitumor activity.
應用(yòng) 雷(léi)公藤甲素是(shì)一種二萜triepoxide，中藥雷(léi)公藤（雷公藤）復合物中提(tí)取的(dí)主要的活性成(chéng)分。它(tā)是(shì)一(yī)種強力(lì)免疫(yì)抑(yì)製劑及(jí)抗發炎劑。雷(léi)公藤(téng)甲(jiǎ)素在活化T細胞(bāo)中已(yǐ)被證明能夠抑製IL - 2因子的表達。在(zài)動物模(mó)型中(zhōng)它協同加強(qiáng)與環(huán)孢素(sù)A在促(cù)進異(yì)基因骨(gǔ)髓移植(zhí)存活(huó)率(shuài)，和對(duì)植物(wù)抗宿主病的(dí)抑製。此(cǐ)外(wài)，誘導腫(zhǒng)瘤(liú)細胞凋亡，通過抑(yì)製c - IAP2和架C - IAP1感(gǎn)應部(bù)分(fēn)地(dì)並增(zēng)強腫瘤壞死(sǐ)因子（TNFα）誘導(dǎo)細(xì)胞凋(diāo)亡。