旋光(guāng)率(shuài) 75 ° (C=0.5, MeOH)
密(mì)度(dù)1.24
熔點 156-157°C
溶解(jiě)性(xìng) Soluble in methanol, ethanol (24 mg/ml) at 25 °C, DMF, DMSO (57 mg/ml) at 25 °C, acetone, chloroform (25 mg/ml), dichloromethane, and ethyl acetate; almost insoluble in water.
描(miáo)述
產(chǎn)品介(jiè)紹 Artemisinin用(yòng)於治(zhì)療(liáo)耐(nài)多(duō)藥的(dí)惡(è)性(xìng)瘧(nüè)疾菌株。
別名 黃花蒿素(sù);(3R,5aS,6R,8aS,9R,10S,12R,12aR)-十(shí)氫(qīng)-3,6,9-三(sān)甲基(jī)-3,12-橋氧-12H-吡(pǐ)喃並[4,3-j]-1,2-苯並(bìng)二塞平(píng)-10-酮;Arteannuin; Qinghaosu;[3R-(3R,5aS,6S,8aS,9R,10R,12S,12aR**)]-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-one
生化機(jī)理 Artemisinin is a powerful antimalarial agent. Artemisinin inhibits angiogenesis by down-regulating HIF-1α and VEGF expression in mouse embryonic stem cells. Artemisinin crosses the blood-brain barrier and is an inhibitor of human NOS2 (iNOS).
應用(yòng) An antimalarial agent that inhibits VEGF expression and NOS2.