英文名(míng)稱：Paclitaxel
CAS號：33069-62-4
分(fēn)析(xī)標準(zhǔn)品(pǐn),≥99%
分(fēn)子(zǐ)式 C47H51NO14 分(fēn)子量(liáng)853.91

基(jī)本信息(xī):

旋光率 -49 ° (C=1, MeOH)
密度1.39
熔點(diǎn) 213-216°C
存(cún)貯條(tiáo)件 儲存(cún)溫(wēn)度2-8°C
描(miáo)述(shù)
產品(pǐn)介(jiè)紹(shào) Paclitaxel是一種微(wēi)管(guǎn)聚合(hé)物(wù)穩定劑(jì)，作用於人內皮細(xì)胞，IC50為(wéi)0.1 pM
別名 Taxol;Taxol
生化機理(lǐ) Taxol, an antineoplastic and antimicrotubule agent, posses mechanisms of cytotoxic action and has a broad antineoplastic spectrum compared to the vinca alkaloids. Studies have shown that Taxol is an inhibitor of neurite outgrowth and initiation by destroying normal control of microtuble assemly in growing neurites and removing tubulin from the cytoplasm. At lower concentrations Taxol displays the capacity to slightly enhance the mechanisms of microtubule assembly in neurons, and in turn changes the morphogenetic properties of growing neurites. The mechanism for microtuble formation occurs by binding of Taxol to the N-terminal region of β-tubulin. These new microtubules are highly stable and resist depolymerization therefore preventing normal cell division and arresting cell cycle at the G2/M phase. It has been reported that Taxol also causes apoptotic cell death, internucleosomal DNA fragmentation, and inhibition of protein isoprenylation. Taxol is a potential activator of PKA and Raf
應(yīng)用(yòng) 有效的抗腫瘤的藥物;結合β-微管蛋(dàn)白的(dí)N -端(duān)區域(yù)，促(cù)進了高度穩(wěn)定的微管(guǎn)形成體，抵製解聚，防(fáng)止正常細胞(bāo)分裂和捕