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英(yīng)文(wén)名稱Anti-ABCB5/FITC
中文名稱(chēng):FITC標(biāo)記的(dí)ATP結合(hé)蛋(dàn)白家族(zú)5抗體
別(bié) 名ATP-binding cassette sub-family B member 5; ABCB 5; ABCB5alpha; ABCB5beta; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; EST422562; P glycoprotein ABCB5; ABCB5_HUMAN.
規格:100ul
說 明 書(shū)100ul
研(yán)究(jiū)領(lǐng)域腫瘤(liú) 信號(hào)轉(zhuǎn)導 通(tōng)道蛋(dàn)白 糖蛋白(bái)
抗體(tǐ)來源Rabbit
克隆(lóng)類(lèi)型Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse,
產(chǎn)品(pǐn)應用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量89/138kDa
細胞定(dìng)位細胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原KLH conjugated synthetic peptide derived from human ABCB5
亞(yà) 型IgG
純化方法(fǎ)affinity purified by Protein A
儲 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品(pǐn)介(jiè)紹background:
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008
Function:
Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
Similarity:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 2 ABC transporter domains.
中文名稱(chēng):FITC標(biāo)記的(dí)ATP結合(hé)蛋(dàn)白家族(zú)5抗體
別(bié) 名ATP-binding cassette sub-family B member 5; ABCB 5; ABCB5alpha; ABCB5beta; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; EST422562; P glycoprotein ABCB5; ABCB5_HUMAN.
詳細(xì)介紹：
規格:100ul
說 明 書(shū)100ul
研(yán)究(jiū)領(lǐng)域腫瘤(liú) 信號(hào)轉(zhuǎn)導 通(tōng)道蛋(dàn)白 糖蛋白(bái)
抗體(tǐ)來源Rabbit
克隆(lóng)類(lèi)型Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow, Horse,
產(chǎn)品(pǐn)應用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量89/138kDa
細胞定(dìng)位細胞膜
性 狀Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原KLH conjugated synthetic peptide derived from human ABCB5
亞(yà) 型IgG
純化方法(fǎ)affinity purified by Protein A
儲 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產品(pǐn)介(jiè)紹background:
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008
Function:
Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues.
Similarity:
Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 2 ABC transporter domains.
