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FITC標記(jì)的(dí)血管(guǎn)緊張(zhāng)素Ⅱ-1型(xíng)受體(tǐ)/抗體(tǐ)
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2017-5-2 瀏(liú)覽次(cì)數：1554
英文名稱(chēng)Anti-Angiotensin II Type 1 Receptor/FITC
中文名稱(chēng):FITC標(biāo)記的(dí)血管(guǎn)緊(jǐn)張(zhāng)素Ⅱ-1型受體(tǐ)/抗體
別(bié) 名AG2S; Agtr 1; Agtr1; Agtr1a; AGTR1B; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; AGTR1_HUMAN; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1R; Ang II; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT1; AT1R.
規(guī)格:100ul
說 明(míng) 書(shū)100ul
研究(jiū)領(lǐng)域(yù)心(xīn)血(xiě)管(guǎn) 細胞生物 細(xì)胞膜(mó)受體
抗(kàng)體來(lái)源(yuán)Rabbit
克隆類(lèi)型Polyclonal
交(jiāo)叉(chā)反應 Human, Mouse, Rat, Cow, Sheep,
產品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
性 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免 疫 原(yuán)KLH conjugated synthetic peptide derived from human AT1R
亞 型(xíng)IgG
純(chún)化方法(fǎ)affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品(pǐn)介(jiè)紹(shào)background:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq]
Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subunit:
Interacts with MAS1 (Probable). Interacts with ARRB1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Liver, lung, adrenal and adrenocortical adenomas.
Post-translational modifications:
C-terminal Ser or Thr residues may be phosphorylated.
DISEASE:
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.
中文名稱(chēng):FITC標(biāo)記的(dí)血管(guǎn)緊(jǐn)張(zhāng)素Ⅱ-1型受體(tǐ)/抗體
別(bié) 名AG2S; Agtr 1; Agtr1; Agtr1a; AGTR1B; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; AT-1B; AT-1r; AT1; At1a; AT1AR; AT1B; AT1BR; AT2R1; AT2R1A; AT2R1B; HAT1R; Type 1 angiotensin II receptor; AGTR1_HUMAN; Type-1 angiotensin II receptor; Angiotensin II type-1 receptor; AT1R; Ang II; Angiotensin II receptor type 1; Angiotensin II type 1 receptor; Angiotensin receptor 1; Angiotensin receptor 1B; AT 1B; AT1; AT1R.
詳細介(jiè)紹：
規(guī)格:100ul
說 明(míng) 書(shū)100ul
研究(jiū)領(lǐng)域(yù)心(xīn)血(xiě)管(guǎn) 細胞生物 細(xì)胞膜(mó)受體
抗(kàng)體來(lái)源(yuán)Rabbit
克隆類(lèi)型Polyclonal
交(jiāo)叉(chā)反應 Human, Mouse, Rat, Cow, Sheep,
產品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量39kDa
性 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免 疫 原(yuán)KLH conjugated synthetic peptide derived from human AT1R
亞 型(xíng)IgG
純(chún)化方法(fǎ)affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資料(liào)：
產品(pǐn)介(jiè)紹(shào)background:
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants. [provided by RefSeq]
Function:
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subunit:
Interacts with MAS1 (Probable). Interacts with ARRB1.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Liver, lung, adrenal and adrenocortical adenomas.
Post-translational modifications:
C-terminal Ser or Thr residues may be phosphorylated.
DISEASE:
Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). Note=The disease is caused by mutations affecting the gene represented in this entry.
