產品中(zhōng)心(xīn)
標(biāo)記一抗
英(yīng)文(wén)名(míng)稱(chēng)Anti-AMIGO2/FITC
中(zhōng)文名稱:FITC標記的(dí)粘(nián)附分(fēn)子IgG樣結(jié)構域(yù)蛋白2抗(kàng)體(tǐ)
別 名Adhesion molecule with Ig like domain 2; ALI 1; ALI1; Alivin 1; Alivin-1; Alivin1; AMIGO 2; Amphoterin induced gene 2; Amphoterin induced protein 2; DEGA; AMGO2_HUMAN; AMIGO-2; Amigo2; Amphoterin induced protein 2; Amphoterin-induced protein 2; Differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; Transmembrane protein AMIGO 2; Transmembrane protein AMIGO2.
規格:100ul
說(shuō) 明 書100ul
研究領(lǐng)域神經(jīng)生(shēng)物學
抗體來源(yuán)Rabbit
克隆類(lèi)型(xíng)Polyclonal
交叉(chā)反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)54kDa
細胞(bāo)定(dìng)位(wèi)細胞(bāo)膜(mó)
性(xìng) 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原KLH conjugated synthetic peptide derived from human AMIGO2
亞 型IgG
純(chún)化方(fāng)法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介(jiè)紹background:
The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction
Function:
A novel primary response gene, AMIGO2, is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human AMIGO2 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse AMIGO2 was mapped to a locus approximately 55.3 cm from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
Subunit:
Binds itself as well as AMIGO1 and AMIGO3 (By similarity).
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Nucleus. Note: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons By
Tissue Specificity:
Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
中(zhōng)文名稱:FITC標記的(dí)粘(nián)附分(fēn)子IgG樣結(jié)構域(yù)蛋白2抗(kàng)體(tǐ)
別 名Adhesion molecule with Ig like domain 2; ALI 1; ALI1; Alivin 1; Alivin-1; Alivin1; AMIGO 2; Amphoterin induced gene 2; Amphoterin induced protein 2; DEGA; AMGO2_HUMAN; AMIGO-2; Amigo2; Amphoterin induced protein 2; Amphoterin-induced protein 2; Differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; Transmembrane protein AMIGO 2; Transmembrane protein AMIGO2.
詳細介紹(shào)：
規格:100ul
說(shuō) 明 書100ul
研究領(lǐng)域神經(jīng)生(shēng)物學
抗體來源(yuán)Rabbit
克隆類(lèi)型(xíng)Polyclonal
交叉(chā)反應(yīng) Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
產品應用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)54kDa
細胞(bāo)定(dìng)位(wèi)細胞(bāo)膜(mó)
性(xìng) 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫(yì) 原KLH conjugated synthetic peptide derived from human AMIGO2
亞 型IgG
純(chún)化方(fāng)法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資(zī)料：
產(chǎn)品介(jiè)紹background:
The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction
Function:
A novel primary response gene, AMIGO2, is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human AMIGO2 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse AMIGO2 was mapped to a locus approximately 55.3 cm from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
Subunit:
Binds itself as well as AMIGO1 and AMIGO3 (By similarity).
Subcellular Location:
Cell membrane; Single-pass type I membrane protein. Nucleus. Note: Associated with nucleus as well as plasma membrane. Restricted to somata of cerebellar as well as hippocampal neurons By
Tissue Specificity:
Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.
