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英文名(míng)稱(chēng)Anti-Aconitase 1/FITC
中文名稱(chēng):FITC標(biāo)記的(dí)鐵調節蛋白1抗體(tǐ)
別 名ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IRE-BP 1; IREB 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; IRP1.
規格:100ul
說(shuō) 明(míng) 書100ul
研(yán)究(jiū)領域(yù)腫瘤 心血管(guǎn) 細胞生物 信(xìn)號轉導 表觀遺(yí)傳學(xué)
抗(kàng)體來源(yuán)Rabbit
克(kè)隆類(lèi)型Polyclonal
交(jiāo)叉反(fǎn)應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
產品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)98kDa
性 狀(zhuàng)Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Aconitase 1/IRP-1
亞(yà) 型(xíng)IgG
純化(huà)方(fāng)法(fǎ)affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹background:
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide
Function:
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Subunit:
Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the aconitase/IPM isomerase family.
中文名稱(chēng):FITC標(biāo)記的(dí)鐵調節蛋白1抗體(tǐ)
別 名ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IRE-BP 1; IREB 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; IRP1.
詳(xiáng)細(xì)介(jiè)紹：
規格:100ul
說(shuō) 明(míng) 書100ul
研(yán)究(jiū)領域(yù)腫瘤 心血管(guǎn) 細胞生物 信(xìn)號轉導 表觀遺(yí)傳學(xué)
抗(kàng)體來源(yuán)Rabbit
克(kè)隆類(lèi)型Polyclonal
交(jiāo)叉反(fǎn)應(yīng) Human, Mouse, Rat, Pig, Cow, Rabbit, Sheep,
產品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)98kDa
性 狀(zhuàng)Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Aconitase 1/IRP-1
亞(yà) 型(xíng)IgG
純化(huà)方(fāng)法(fǎ)affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資(zī)料：
產(chǎn)品介紹background:
Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins; iron regulatory protein-1 and -2 (IRP-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE–BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide
Function:
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Subunit:
Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
Subcellular Location:
Cytoplasm.
Similarity:
Belongs to the aconitase/IPM isomerase family.
- 上(shàng)一條：FITC標記的陰離(lí)子(zǐ)交(jiāo)換(huàn)蛋(dàn)白2抗(kàng)體
- 下(xià)一條(tiáo)：FITC標記的載(zǎi)脂蛋(dàn)白E抗體
