產品(pǐn)中(zhōng)心
標(biāo)記(jì)一抗
英文(wén)名稱Anti-alpha 2 Macroglobulin/FITC
中(zhōng)文(wén)名(míng)稱(chēng):FITC標記(jì)的α2巨球(qiú)蛋(dàn)白(α-2M)抗體
別 名(míng)A2M; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7.
規(guī)格(gé):100ul
說 明 書100ul
研究(jiū)領域細胞生物 免(miǎn)疫學
抗(kàng)體(tǐ)來源Rabbit
克隆類型(xíng)Polyclonal
交(jiāo)叉(chā)反(fǎn)應 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
產品(pǐn)應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)160kDa
性(xìng) 狀Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免(miǎn) 疫(yì) 原(yuán)KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin
亞 型IgG
純化方(fāng)法affinity purified by Protein A
儲 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹background:
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subunit:
Homotetramer; disulfide-linked.
Subcellular Location:
Secreted
Tissue Specificity:
Secreted in plasma
Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
中(zhōng)文(wén)名(míng)稱(chēng):FITC標記(jì)的α2巨球(qiú)蛋(dàn)白(α-2M)抗體
別 名(míng)A2M; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7.
詳細介紹(shào)：
規(guī)格(gé):100ul
說 明 書100ul
研究(jiū)領域細胞生物 免(miǎn)疫學
抗(kàng)體(tǐ)來源Rabbit
克隆類型(xíng)Polyclonal
交(jiāo)叉(chā)反(fǎn)應 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit,
產品(pǐn)應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)160kDa
性(xìng) 狀Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免(miǎn) 疫(yì) 原(yuán)KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin
亞 型IgG
純化方(fāng)法affinity purified by Protein A
儲 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條(tiáo)件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資料(liào)：
產品介紹background:
Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subunit:
Homotetramer; disulfide-linked.
Subcellular Location:
Secreted
Tissue Specificity:
Secreted in plasma
Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
- 上一(yī)條：FITC標記的(dí)蛋白(bái)激酶A2抗體(tǐ)
- 下一(yī)條(tiáo)：FITC標記(jì)的ACCSL蛋(dàn)白(bái)抗體
