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英(yīng)文名(míng)稱(chēng)Anti-ARS2/FITC
中文名(míng)稱:FITC標記的砷酸鹽(yán)耐(nài)藥蛋白ARS2抗體
別(bié) 名(míng)ARS2 protein; Arsenate resistance protein ARS2; Arsenite resistance protein 2; Arsenite resistance protein; ASR2; MGC126427; Serrate; Serrate RNA effector molecule homolog (Arabidopsis); Serrate RNA effector molecule homolog; SRRT; SRRT_HUMAN.
規(guī)格:100ul
說 明 書100ul
研(yán)究領域細胞生物(wù) 免(miǎn)疫學 轉(zhuǎn)錄調(tiáo)節因(yīn)子
抗體來源(yuán)Rabbit
克(kè)隆類型Polyclonal
交(jiāo)叉反(fǎn)應 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
產品(pǐn)應(yīng)用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量101kDa
性(xìng) 狀Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免 疫 原(yuán)KLH conjugated synthetic peptide derived from human ARS2 (721-760aa)
亞 型IgG
純(chún)化方法(fǎ)affinity purified by Protein A
儲(chǔ) 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹(shào)background:
ARS2(Arsenite resistance protein 2) confers arsenite resistance. The protein belongs to the ARS2 family. Arsenic is a human carcinogen whose mechanism of action is unknown. The arsenite acts as a comutagen by interfering with DNA repair. Two genes, ASR1(Arsenite resistance protein 1) and ASR2 (Arsenite resistance protein 2), confer arsenite resistance to arsenite-sensitive cells. ASR1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin like region fused to S30 ribosomal protein. Arsenite inhibits ubiquitin dependent proteolysis. The tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite
Subunit:
Interacts with NCBP1 and DROSHA. Interacts with CASP8AP2 and ERBB4.
Subcellular Location:
Nucleus. Cytoplasm.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the ARS2 family.
Database links:
UniProtKB/Swiss-Prot: Q9BXP5.1
中文名(míng)稱:FITC標記的砷酸鹽(yán)耐(nài)藥蛋白ARS2抗體
別(bié) 名(míng)ARS2 protein; Arsenate resistance protein ARS2; Arsenite resistance protein 2; Arsenite resistance protein; ASR2; MGC126427; Serrate; Serrate RNA effector molecule homolog (Arabidopsis); Serrate RNA effector molecule homolog; SRRT; SRRT_HUMAN.
詳(xiáng)細介(jiè)紹：
規(guī)格:100ul
說 明 書100ul
研(yán)究領域細胞生物(wù) 免(miǎn)疫學 轉(zhuǎn)錄調(tiáo)節因(yīn)子
抗體來源(yuán)Rabbit
克(kè)隆類型Polyclonal
交(jiāo)叉反(fǎn)應 Human, Mouse, Rat, Dog, Pig, Cow, Horse,
產品(pǐn)應(yīng)用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量101kDa
性(xìng) 狀Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免 疫 原(yuán)KLH conjugated synthetic peptide derived from human ARS2 (721-760aa)
亞 型IgG
純(chún)化方法(fǎ)affinity purified by Protein A
儲(chǔ) 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資(zī)料：
產(chǎn)品介紹(shào)background:
ARS2(Arsenite resistance protein 2) confers arsenite resistance. The protein belongs to the ARS2 family. Arsenic is a human carcinogen whose mechanism of action is unknown. The arsenite acts as a comutagen by interfering with DNA repair. Two genes, ASR1(Arsenite resistance protein 1) and ASR2 (Arsenite resistance protein 2), confer arsenite resistance to arsenite-sensitive cells. ASR1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin like region fused to S30 ribosomal protein. Arsenite inhibits ubiquitin dependent proteolysis. The tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite
Subunit:
Interacts with NCBP1 and DROSHA. Interacts with CASP8AP2 and ERBB4.
Subcellular Location:
Nucleus. Cytoplasm.
Tissue Specificity:
Ubiquitously expressed.
Similarity:
Belongs to the ARS2 family.
Database links:
UniProtKB/Swiss-Prot: Q9BXP5.1
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