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英(yīng)文(wén)名稱(chēng)Anti-ApoER2/FITC
中文名稱(chēng):FITC標(biāo)記的載脂蛋(dàn)白E2受(shòu)體(tǐ)抗體(tǐ)
別(bié) 名APOER2; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8; Low-density lipoprotein receptor-related protein 8; LRP-8; LRP8; LRP8_HUMAN.
規格:100ul
說 明 書(shū)100ul
研究領(lǐng)域(yù)心(xīn)血管 神經生物學(xué) 信號轉導(dǎo) 細(xì)胞膜受(shòu)體 細胞自噬
抗體來源(yuán)Rabbit
克(kè)隆(lóng)類型(xíng)Polyclonal
交(jiāo)叉(chā)反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
產品(pǐn)應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)102kDa
細胞定(dìng)位細(xì)胞(bāo)膜
性 狀(zhuàng)Lyophilized or Liquid
濃(nóng) 度1mg/ml
免(miǎn) 疫 原(yuán)KLH conjugated synthetic peptide derived from human ApoER2
亞 型IgG
純化方(fāng)法(fǎ)affinity purified by Protein A
儲(chǔ) 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存(cún)條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹(shào)background:
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
中文名稱(chēng):FITC標(biāo)記的載脂蛋(dàn)白E2受(shòu)體(tǐ)抗體(tǐ)
別(bié) 名APOER2; Apolipoprotein E receptor 2; low density lipoprotein receptor-related protein 8; Low-density lipoprotein receptor-related protein 8; LRP-8; LRP8; LRP8_HUMAN.
詳(xiáng)細介(jiè)紹(shào)：
規格:100ul
說 明 書(shū)100ul
研究領(lǐng)域(yù)心(xīn)血管 神經生物學(xué) 信號轉導(dǎo) 細(xì)胞膜受(shòu)體 細胞自噬
抗體來源(yuán)Rabbit
克(kè)隆(lóng)類型(xíng)Polyclonal
交(jiāo)叉(chā)反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
產品(pǐn)應(yīng)用ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)102kDa
細胞定(dìng)位細(xì)胞(bāo)膜
性 狀(zhuàng)Lyophilized or Liquid
濃(nóng) 度1mg/ml
免(miǎn) 疫 原(yuán)KLH conjugated synthetic peptide derived from human ApoER2
亞 型IgG
純化方(fāng)法(fǎ)affinity purified by Protein A
儲(chǔ) 存(cún) 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存(cún)條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相(xiāng)關資料(liào)：
產品介紹(shào)background:
Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor.
- 上(shàng)一條：FITC標記的腺(xiàn)苷A1受(shòu)體抗(kàng)體
- 下一(yī)條(tiáo)：FITC標記(jì)的(dí)水通(tōng)道(dào)蛋白(bái)0抗體
