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英(yīng)文(wén)名(míng)稱Anti-ATK/BTK/FITC
中文(wén)名(míng)稱:FITC標記(jì)的酪(lào)氨酸蛋(dàn)白激(jī)酶BTK抗(kàng)體
別 名(míng)Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton’s Tyrosine Kinase; Btk; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP; PSCTK 1; PSCTK1; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; XLA.
規(guī)格:100ul
說 明 書(shū)100ul
研(yán)究(jiū)領域激酶(méi)和(hé)磷酸酶
抗(kàng)體(tǐ)來源(yuán)Rabbit
克(kè)隆類(lèi)型Polyclonal
交叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
產(chǎn)品(pǐn)應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)76kDa
細(xì)胞定位細(xì)胞(bāo)膜
性(xìng) 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human BTK
亞 型IgG
純(chún)化(huà)方法(fǎ)affinity purified by Protein A
儲 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品(pǐn)介(jiè)紹background:
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.
中文(wén)名(míng)稱:FITC標記(jì)的酪(lào)氨酸蛋(dàn)白激(jī)酶BTK抗(kàng)體
別 名(míng)Agammaglobulinaemia tyrosine kinase; AGMX 1; AGMX1; AT; ATK; B cell progenitor kinase; B-cell progenitor kinase; BPK; Bruton agammaglobulinemia tyrosine kinase; Bruton tyrosine kinase; Bruton’s Tyrosine Kinase; Btk; BTK_HUMAN; IMD 1; IMD1; MGC126261; MGC126262; OTTHUMP; PSCTK 1; PSCTK1; Tyrosine protein kinase BTK; Tyrosine-protein kinase BTK; XLA.
詳細(xì)介(jiè)紹：
規(guī)格:100ul
說 明 書(shū)100ul
研(yán)究(jiū)領域激酶(méi)和(hé)磷酸酶
抗(kàng)體(tǐ)來源(yuán)Rabbit
克(kè)隆類(lèi)型Polyclonal
交叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
產(chǎn)品(pǐn)應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)76kDa
細(xì)胞定位細(xì)胞(bāo)膜
性(xìng) 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human BTK
亞 型IgG
純(chún)化(huà)方法(fǎ)affinity purified by Protein A
儲 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相(xiāng)關資料(liào)：
產(chǎn)品(pǐn)介(jiè)紹background:
Brutons tyrosine kinase (BTK) is a member of the BTK/Tec family of cytoplasmic tyrosine kinases. Like other BTK family members, it contains a pleckstrin homology (PH) domain, Src homology SH3 and SH2 domains. BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation. The activation of BTK is negatively regulated by PKC beta through phosphorylation of BTK at Ser180, which results in reduced membrane recruitment, transphosphorylation and subsequent activation. The PKC/BTK inhibitory signal is likely to be a key determinant of the B cell receptor signaling threshold to maintain optimal BTK activity.
