產品(pǐn)中(zhōng)心
一抗
英(yīng)文名稱 Anti-APCL/APC2
中文名(míng)稱(chēng) 腺瘤性(xìng)結腸(cháng)息(xī)肉病蛋白2抗體
別 名(míng) Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN.
濃 度(dù) 1mg/1ml
規(guī) 格 0.2ml/200μg
抗(kàng)體來(lái)源(yuán) Rabbit
克隆(lóng)類(lèi)型(xíng) polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Dog, Pig, Horse
產品類型(xíng) 一抗
研(yán)究領域 腫(zhǒng)瘤 免疫(yì)學(xué) 細胞粘(nián)附分子(zǐ) 細胞骨架(jià)
蛋(dàn)白(bái)分子(zǐ)量(liáng) predicted molecular weight: 244kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human APCL/APC2
亞(yà) 型 IgG
純(chún)化方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需(xū)做(zuò)抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品(pǐn)介紹 The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin.
Function : APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.
Subunit : Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.
Subcellular Location : Cell Membrane, Cytoplasmic and Golgi Apparatus
Tissue Specificity : Widely expressed (at protein level). Specifically expressed in the CNS.
Similarity : Belongs to the adenomatous polyposis coli (APC) family.
Contains 6 ARM repeats.
Database links : UniProtKB/Swiss-Prot: O95996.1
中文名(míng)稱(chēng) 腺瘤性(xìng)結腸(cháng)息(xī)肉病蛋白2抗體
別 名(míng) Adenomatous polyposis coli protein 2; Adenomatous polyposis coli protein-like; APCL; APC2_HUMAN.
詳(xiáng)細(xì)介(jiè)紹：
濃 度(dù) 1mg/1ml
規(guī) 格 0.2ml/200μg
抗(kàng)體來(lái)源(yuán) Rabbit
克隆(lóng)類(lèi)型(xíng) polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Dog, Pig, Horse
產品類型(xíng) 一抗
研(yán)究領域 腫(zhǒng)瘤 免疫(yì)學(xué) 細胞粘(nián)附分子(zǐ) 細胞骨架(jià)
蛋(dàn)白(bái)分子(zǐ)量(liáng) predicted molecular weight: 244kDa
性 狀(zhuàng) Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human APCL/APC2
亞(yà) 型 IgG
純(chún)化方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需(xū)做(zuò)抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相(xiāng)關資料(liào)：
產(chǎn)品(pǐn)介紹 The adenomatous polyposis syndromes, familial adenomatous polyposis (FAP) and Gardner’s syndrome (GS), are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin (also called plakoglobin) are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin.
Function : APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.
Subunit : Interacts with PSRC1 (By similarity). Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2.
Subcellular Location : Cell Membrane, Cytoplasmic and Golgi Apparatus
Tissue Specificity : Widely expressed (at protein level). Specifically expressed in the CNS.
Similarity : Belongs to the adenomatous polyposis coli (APC) family.
Contains 6 ARM repeats.
Database links : UniProtKB/Swiss-Prot: O95996.1
