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一(yī)抗
英(yīng)文(wén)名稱(chēng) Anti-BAMBI
濃(nóng) 度 1mg/1ml
規 格(gé) 0.2ml/200μg
抗體(tǐ)來(lái)源 Rabbit
克(kè)隆類(lèi)型 polyclonal
交叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Cow, Sheep
產品類(lèi)型 一(yī)抗
研究領域(yù) 腫(zhǒng)瘤 幹細胞(bāo) 生(shēng)長(cháng)因子和(hé)激素(sù) 細胞(bāo)表麵分(fēn)子(zǐ)
蛋白(bái)分(fēn)子量 predicted molecular weight: 27kDa
性(xìng) 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human BAMBI
亞(yà) 型 IgG
純化方法(fǎ) affinity purified by Protein A
儲(chǔ) 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟(là)切片需做(zuò)抗原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保(bǎo)存(cún)條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹 BAMBI is a membrane spanning glycoprotein that acts as a negative regulator of TGF-β signaling during development. The BAMBI family of proteins are related to type I TGF-β receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of β-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
Function : Negatively regulates TGF-beta signaling.
Subcellular Location : Membrane.
Tissue Specificity : High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
Similarity : Belongs to the BAMBI family.
Database links : UniProtKB/Swiss-Prot: Q13145.1
中文名(míng)稱：腫瘤轉(zhuǎn)移(yí)抑製(zhì)蛋白(bái)BAMBI抗體
別(bié) 名 BAMBI; BAMBI_HUMAN; BMP and activin membrane bound inhibitor homolog; BMP and activin membrane-bound inhibitor homolog; NMA; Non metastatic gene A protein; Non-metastatic gene A protein; Putative transmembrane protein NMA.詳(xiáng)細(xì)介(jiè)紹：
濃(nóng) 度 1mg/1ml
規 格(gé) 0.2ml/200μg
抗體(tǐ)來(lái)源 Rabbit
克(kè)隆類(lèi)型 polyclonal
交叉(chā)反(fǎn)應 Human, Mouse, Rat, Dog, Cow, Sheep
產品類(lèi)型 一(yī)抗
研究領域(yù) 腫(zhǒng)瘤 幹細胞(bāo) 生(shēng)長(cháng)因子和(hé)激素(sù) 細胞(bāo)表麵分(fēn)子(zǐ)
蛋白(bái)分(fēn)子量 predicted molecular weight: 27kDa
性(xìng) 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human BAMBI
亞(yà) 型 IgG
純化方法(fǎ) affinity purified by Protein A
儲(chǔ) 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟(là)切片需做(zuò)抗原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保(bǎo)存(cún)條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資料：
產品介紹 BAMBI is a membrane spanning glycoprotein that acts as a negative regulator of TGF-β signaling during development. The BAMBI family of proteins are related to type I TGF-β receptor family, however, BAMBI is a pseudoreceptor that lacks an intracellular serine/threonine kinase domain. BAMBI transcription regulation is under the influence of β-catenin, BMP, smad3 and smad4. BAMBI expression can increase in colorectal and hepatocellular carcinomas relative to non-cancerous tissues. BAMBI is expressed at high levels during odontogenesis. BAMBI is coexpressed with Bmp-4 during early Xenopus embryogenesis and can be detected in poorly metastatic human melanoma cell lines.
Function : Negatively regulates TGF-beta signaling.
Subcellular Location : Membrane.
Tissue Specificity : High expression in kidney medulla, placenta and spleen; low in kidney cortex, liver, prostate and gut. Not expressed in normal skin, expression is high in melanocytes and in 3 out of 11 melanoma metastases tested.
Similarity : Belongs to the BAMBI family.
Database links : UniProtKB/Swiss-Prot: Q13145.1
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