產品中心(xīn)
一(yī)抗
英文名(míng)稱 Anti-BACH2
中文名稱： 轉錄調(tiáo)節蛋白BACH2抗體
別 名 Bach 2; Bach2; BACH2_HUMAN; Basic leucine zipper transcription factor 2; BTB and CNC homolog 2; BTB and CNC homology 1 basic leucine zipper transcription factor 2; OTTHUMP; OTTHUMP; OTTHUMP; Transcription regulator protein BACH2.
濃 度(dù) 1mg/1ml
規(guī) 格 0.2ml/200μg
抗(kàng)體(tǐ)來(lái)源(yuán) Rabbit
克(kè)隆(lóng)類(lèi)型 polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep
產(chǎn)品類(lèi)型(xíng) 一(yī)抗(kàng)
研(yán)究領域 腫瘤 細(xì)胞(bāo)生(shēng)物 信號轉導 轉(zhuǎn)錄調節(jié)因子(zǐ) 淋巴(bā)細胞 b-淋巴細(xì)胞(bāo) 新陳(chén)代謝(xiè)
蛋白分子量 predicted molecular weight: 92kDa
性 狀 Lyophilized or Liquid
免 疫 原(yuán) KLH conjugated synthetic peptide derived from human BACH2
亞 型 IgG
純化(huà)方法(fǎ) affinity purified by Protein A
儲(chǔ) 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應(yīng)用(yòng) WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切(qiē)片(piàn)需做(zuò)抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介(jiè)紹 Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors. They dimerize with other proteins and bind DNA to either represse or activate transcription depending on the dimer compositions. BACH1 and BACH2, heterodimerization partners of MafK, are members of a novel family of BTB/POZ-basic region leucine zipper (bzip) factors. BACH1 and BACH2 have significant similarity to each other in BTB domain and Cap ‘n’ collar-type bZip domain but are otherwise divergent. BACH1 appears ubiquitous, whereas BACH2 is restricted to monocytes, neuronal cells and is abundantly expressed in the early stages of B-cell differentiation. BACH2, a 841 amino acid polypeptide, is an Nrf2-related transcription repressor and a tissue-specific partner of the Maf oncoprotein family. In culture cells, BACH2 is localized to the cytoplasm through its C-terminal cytoplasmic localization signal (CLS). Oxidative stressors aborted the CLS activity and induce nuclear accumulation of BACH2, which mediates nucleocytoplasmic communciation to couple oxidative stress and transcription repression in mammalian cells. BACH2 heterodimerizes with MAZR through its BTB/POZ domain to activate transcription. BACH2 also plays an important role in the regulation of B cell development.
Function : Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK.
Subunit : Heterodimer of BACH2 and Maf-related transcription factors (By similarity).
Subcellular Location : Nucleus.
Tissue Specificity : B-cell specific.
Similarity : Belongs to the bZIP family. CNC subfamily.
Contains 1 BTB (POZ) domain.
Contains 1 bZIP domain.
Database links : UniProtKB/Swiss-Prot: Q9BYV9.1
中文名稱： 轉錄調(tiáo)節蛋白BACH2抗體
別 名 Bach 2; Bach2; BACH2_HUMAN; Basic leucine zipper transcription factor 2; BTB and CNC homolog 2; BTB and CNC homology 1 basic leucine zipper transcription factor 2; OTTHUMP; OTTHUMP; OTTHUMP; Transcription regulator protein BACH2.
詳(xiáng)細介紹：
濃 度(dù) 1mg/1ml
規(guī) 格 0.2ml/200μg
抗(kàng)體(tǐ)來(lái)源(yuán) Rabbit
克(kè)隆(lóng)類(lèi)型 polyclonal
交(jiāo)叉反應 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep
產(chǎn)品類(lèi)型(xíng) 一(yī)抗(kàng)
研(yán)究領域 腫瘤 細(xì)胞(bāo)生(shēng)物 信號轉導 轉(zhuǎn)錄調節(jié)因子(zǐ) 淋巴(bā)細胞 b-淋巴細(xì)胞(bāo) 新陳(chén)代謝(xiè)
蛋白分子量 predicted molecular weight: 92kDa
性 狀 Lyophilized or Liquid
免 疫 原(yuán) KLH conjugated synthetic peptide derived from human BACH2
亞 型 IgG
純化(huà)方法(fǎ) affinity purified by Protein A
儲(chǔ) 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應(yīng)用(yòng) WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切(qiē)片(piàn)需做(zuò)抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相(xiāng)關資(zī)料：
產(chǎn)品介(jiè)紹 Members of the small Maf family (MafK, MafF, and MafG) are basic region leucine zipper (bZip) proteins that can function as transcriptional activators or repressors. They dimerize with other proteins and bind DNA to either represse or activate transcription depending on the dimer compositions. BACH1 and BACH2, heterodimerization partners of MafK, are members of a novel family of BTB/POZ-basic region leucine zipper (bzip) factors. BACH1 and BACH2 have significant similarity to each other in BTB domain and Cap ‘n’ collar-type bZip domain but are otherwise divergent. BACH1 appears ubiquitous, whereas BACH2 is restricted to monocytes, neuronal cells and is abundantly expressed in the early stages of B-cell differentiation. BACH2, a 841 amino acid polypeptide, is an Nrf2-related transcription repressor and a tissue-specific partner of the Maf oncoprotein family. In culture cells, BACH2 is localized to the cytoplasm through its C-terminal cytoplasmic localization signal (CLS). Oxidative stressors aborted the CLS activity and induce nuclear accumulation of BACH2, which mediates nucleocytoplasmic communciation to couple oxidative stress and transcription repression in mammalian cells. BACH2 heterodimerizes with MAZR through its BTB/POZ domain to activate transcription. BACH2 also plays an important role in the regulation of B cell development.
Function : Transcriptional regulator that acts as repressor or activator. Binds to Maf recognition elements (MARE). Play important roles in coordinating transcription activation and repression by MAFK.
Subunit : Heterodimer of BACH2 and Maf-related transcription factors (By similarity).
Subcellular Location : Nucleus.
Tissue Specificity : B-cell specific.
Similarity : Belongs to the bZIP family. CNC subfamily.
Contains 1 BTB (POZ) domain.
Contains 1 bZIP domain.
Database links : UniProtKB/Swiss-Prot: Q9BYV9.1
- 上一條(tiáo)：肌(jī)動蛋(dàn)白樣(yàng)蛋白6A抗(kàng)體
- 下一(yī)條：磷(lín)酸化轉錄因子MYB相(xiāng)關蛋(dàn)白B抗體
