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英(yīng)文名(míng)稱 Anti-BRD3
中文名稱： BRD3蛋白(bái)抗體(tǐ)
別 名(míng) BRD 3; Brd3; BRD3_HUMAN; Bromodomain containing 3; Bromodomain containing protein 3; Bromodomain-containing protein 3; KIAA0043; Open reading frame X; ORFX; RING3 like gene; RING3-like protein; RING3L.
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源 Rabbit
克隆類(lèi)型 polyclonal
交(jiāo)叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse
產品類(lèi)型 一(yī)抗
研(yán)究領域 細胞(bāo)生物 免(miǎn)疫學 信號轉導 表觀遺傳(chuán)學(xué)
蛋白分(fēn)子量 predicted molecular weight: 80kDa
性 狀 Lyophilized or Liquid
免(miǎn) 疫(yì) 原(yuán) KLH conjugated synthetic peptide derived from human BRD3
亞 型 IgG
純(chún)化(huà)方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟(là)切(qiē)片(piàn)需做(zuò)抗(kàng)原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介(jiè)紹 The bromodomain-containing proteins include BRD2, BRD3, BRD4 and BRDT. BRD2 (RING3 protein) is a mitogen-activated nuclear protein whose gene is located in the human MHC II region, suggesting its relation to HLA-associated diseases. The gene encoding BRD3 (RING3-like protein) contains two bromodomains and maps to chromosome 9q34. BRD4 (HUNK1 protein) is a nuclear protein involved in the regulation of chromosomal dynamics during mitosis. The testis-specific bromodomain protein BRDT contains a PEST sequence, indicating that it undergoes rapid intracellular degradation. The bromodomain-containing proteins are ubiquitously expressed.
Function : Binds hyperacetylated chromatin and plays a role in theregulation of transcription, probably by chromatin remodeling andinteraction with transcription factors. Regulates transcription bypromoting the binding of the transcription factor GATA1 to itstargets (By similarity). Regulates transcription of the CCND1 gene.
Subunit : Interacts (via bromo domain 1) with GATA1 acetylated at'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2acetylated on lysine residues (By similarity). Interacts (via bromodomains) with acetylated lysine residues on the N-terminus ofhistone H2A, H2B, H3 and H4 (in vitro).
Subcellular Location : Nucleus.
Tissue Specificity : Ubiquitous.
DISEASE : Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
Similarity : Contains 2 bromo domains.
Database links : UniProtKB/Swiss-Prot: Q15059.1
中文名稱： BRD3蛋白(bái)抗體(tǐ)
別 名(míng) BRD 3; Brd3; BRD3_HUMAN; Bromodomain containing 3; Bromodomain containing protein 3; Bromodomain-containing protein 3; KIAA0043; Open reading frame X; ORFX; RING3 like gene; RING3-like protein; RING3L.
詳細(xì)介紹：
濃 度 1mg/1ml
規 格 0.2ml/200μg
抗體來源 Rabbit
克隆類(lèi)型 polyclonal
交(jiāo)叉反應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse
產品類(lèi)型 一(yī)抗
研(yán)究領域 細胞(bāo)生物 免(miǎn)疫學 信號轉導 表觀遺傳(chuán)學(xué)
蛋白分(fēn)子量 predicted molecular weight: 80kDa
性 狀 Lyophilized or Liquid
免(miǎn) 疫(yì) 原(yuán) KLH conjugated synthetic peptide derived from human BRD3
亞 型 IgG
純(chún)化(huà)方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟(là)切(qiē)片(piàn)需做(zuò)抗(kàng)原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條(tiáo)件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相(xiāng)關資料：
產(chǎn)品介(jiè)紹 The bromodomain-containing proteins include BRD2, BRD3, BRD4 and BRDT. BRD2 (RING3 protein) is a mitogen-activated nuclear protein whose gene is located in the human MHC II region, suggesting its relation to HLA-associated diseases. The gene encoding BRD3 (RING3-like protein) contains two bromodomains and maps to chromosome 9q34. BRD4 (HUNK1 protein) is a nuclear protein involved in the regulation of chromosomal dynamics during mitosis. The testis-specific bromodomain protein BRDT contains a PEST sequence, indicating that it undergoes rapid intracellular degradation. The bromodomain-containing proteins are ubiquitously expressed.
Function : Binds hyperacetylated chromatin and plays a role in theregulation of transcription, probably by chromatin remodeling andinteraction with transcription factors. Regulates transcription bypromoting the binding of the transcription factor GATA1 to itstargets (By similarity). Regulates transcription of the CCND1 gene.
Subunit : Interacts (via bromo domain 1) with GATA1 acetylated at'Lys-312' and 'Lys-315'. Interacts (via bromo domain 1) with GATA2acetylated on lysine residues (By similarity). Interacts (via bromodomains) with acetylated lysine residues on the N-terminus ofhistone H2A, H2B, H3 and H4 (in vitro).
Subcellular Location : Nucleus.
Tissue Specificity : Ubiquitous.
DISEASE : Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
Similarity : Contains 2 bromo domains.
Database links : UniProtKB/Swiss-Prot: Q15059.1
