產(chǎn)品中(zhōng)心(xīn)
一抗
英文名(míng)稱 Anti-CEA/CD66e/CEACAM5(C-terminus)
中文(wén)名(míng)稱 癌胚抗原(yuán)抗體（C端(duān)）
別 名 Carcino Embryonic Antigen CEA; CEACAM 5; CEACAM-5; Carcinoembryonic antigen; Carcinoembryonic antigen related cell adhesion molecule 5; CD66e; CD66e antigen; CEA; CEACAM5; DKFZp781M2392; Meconium antigen 100.
詳細(xì)介紹(shào)：
濃 度(dù) 1mg/1ml
規 格(gé) 0.1ml/100μg 0.2ml/200μg
抗體(tǐ)來(lái)源(yuán) Rabbit
克隆類(lèi)型 polyclonal
交叉反(fǎn)應 Human
產品(pǐn)類型(xíng) 一(yī)抗(kàng)
研究領域(yù) 腫瘤(liú) 免(miǎn)疫學 幹細胞(bāo) 細胞類型標(biāo)誌物(wù) 腫瘤(liú)細胞(bāo)生物(wù)標誌物
蛋白分(fēn)子量(liáng) predicted molecular weight: 150-200kDa
性(xìng) 狀 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human CEA/CD66e/CEACAM5(C-terminus)
亞 型 IgG
純化(huà)方(fāng)法 affinity purified by Protein A
儲 存(cún) 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品應用(yòng) WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟切(qiē)片需(xū)做抗(kàng)原(yuán)修(xiū)復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保(bǎo)存條(tiáo)件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關(guān)資料：
產品(pǐn)介紹(shào) CEA-related cell adhesion molecules (CEACAM) belong to the carcinoembryonic antigen (CEA) family. It consists of seven CEACAM (CEACAM 1, CEACAM 3-CEACAM 8) and 11 pregnancy-specific glyco-protein (PSG 1-PSG 11) members. The CEA family proteins belong to the immunoglobulin (Ig) superfamily and are composed of one Ig variable-like (IgV) and a varying number (0-6) of Ig constant-like (IgC) domains. CEACAM molecules are membrane-bound either via a transmembrane domain or a glycosyl phosphatidyl inositol (GPI) anchor. CEACAM molecules are differentially expressed in epithelial cells or in leucocytes. Over-expression of CEA/ CEACAM 5 in tumors of epithelial origin is the basis of its wide-spread use as a tumor marker. The function of CEACAM family members varies widely: they function as cell adhesion molecules, tumor suppressors, regulators of lymphocyte and dendritic cell activation, receptors of Neisseria species and other bacteria.
Function : Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.
Subunit : Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
Subcellular Location : Cell membrane; Lipid-anchor, GPI-anchor
Tissue Specificity : Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Similarity : Belongs to the immunoglobulin superfamily. CEA family.
CEA是一種(zhǒng)胚胎性(xìng)抗(kàng)原(yuán)，主要存在於胎(tāi)兒消化道(dào)上(shàng)皮(pí)組(zǔ)織，胰腺和肝癌中。CEA廣泛(fàn)存(cún)在各種(zhǒng)上皮性(xìng)腫(zhǒng)瘤，尤其是胃腸道(dào)惡(è)性(xìng)腫瘤，CEA分布(bù)陽性類型與腫(zhǒng)瘤(liú)的(dí)惡(è)性度有關。CEA與EMA一樣可作為上(shàng)皮性(xìng)惡(è)性腫瘤的重要(yào)標記(jì)
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