產(chǎn)品中(zhōng)心
一(yī)抗
磷(lín)酸化絲氨酸/蘇氨(ān)酸(suān)蛋白(bái)激酶(méi)II β/casein kinase IIβ抗體
英文(wén)名(míng)稱 Anti-phospho-CK II beta (Ser209)
中文名稱(chēng) 磷酸(suān)化(huà)絲(sī)氨(ān)酸/蘇(sū)氨(ān)酸(suān)蛋(dàn)白激酶(méi)II β/casein kinase IIβ抗(kàng)體
別 名 Casein Kinase 2 beta (phospho S209); p-Casein Kinase 2 beta (phospho S209); Casein Kinase 2 beta (p-S209); p-CSK2B(Ser209); phospho-CSK2B(Ser209); Casein kinase 2 beta polypeptide; casein kinase IIβ; Casein kinase II subunit beta;
詳(xiáng)細介紹(shào)：
濃 度 1mg/1ml
規(guī) 格 0.1ml/100μg
抗(kàng)體來(lái)源(yuán) Rabbit
克(kè)隆(lóng)類型 polyclonal
交叉反(fǎn)應 Human, Mouse, Rat, Pig, Cow
產品類(lèi)型(xíng) 一抗 磷(lín)酸(suān)化(huà)抗(kàng)體(tǐ)
研(yán)究領(lǐng)域 腫瘤 細胞(bāo)生物(wù) 信(xìn)號轉(zhuǎn)導 細(xì)胞周期蛋(dàn)白 轉錄(lù)調(tiáo)節(jié)因(yīn)子(zǐ) 激酶和(hé)磷(lín)酸(suān)酶
蛋白(bái)分子量(liáng) predicted molecular weight: 24kDa
性 狀 Lyophilized or Liquid
免(miǎn) 疫(yì) 原(yuán) KLH conjugated synthesised phosphopeptide derived from human CK II beta around the phosphorylation site of Ser209
亞 型(xíng) IgG
純(chún)化方(fāng)法 affinity purified by Protein A
儲(chǔ) 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品(pǐn)應用(yòng) WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟切片需做抗原(yuán)修(xiū)復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存條件(jiàn) Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資料(liào)：
產(chǎn)品介紹(shào) This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008].
Function : Participates in Wnt signaling (By similarity). Plays a complex role in regulating the basal catalytic activity of the alpha subunit.
Subunit : Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2.
Post-translational modifications : Phosphorylated by alpha subunit.
Similarity : Belongs to the casein kinase 2 subunit beta family.
Database links : UniProtKB/Swiss-Prot: P67870.1
