產(chǎn)品(pǐn)編號(hào)：Y3182
英(yīng)文名稱：(-)-Epigallocatechin gallate
CAS號 989-51-5  
分(fēn)析標(biāo)準品(pǐn)
分(fēn)子式 C22H18O11 分子(zǐ)量(liáng)458.37

基本信息:

旋光(guāng)率 -175.5 ° (C=1, EtOH)
密度 1.9
熔點(diǎn) 212°C
溶(róng)解性 Soluble in ethanol (~20 mg/ml), dimethyl formamide (~20 mg/ml), DMSO (~20 mg/ml), water (>5 mg/ml), DMF, PBS pH 7.2, and Methanol.
存(cún)貯條件 儲(chǔ)存溫度(dù) 2-8°C
描述 
產(chǎn)品介(jiè)紹(shào) (-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, reported to have broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDLs) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells in vitro, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. EGCG also inhibits NOS2 (iNOS).
別(bié)名 (-)-順(shùn)式-2-(3,4,5-三(sān)羥基(jī)苯(běn)基)-3,4-二氫(qīng)-1(2H)-苯並吡(pǐ)喃-3,5,7--三(sān)醇;3-沒食子酸(suān)酯(zhǐ);(-)-順式-3,3′,4′,5,5′,7-六羥(qiǎng)基(jī)-黃烷-3-沒食子(zǐ)酸(suān)酯(zhǐ);EGCG;;(-)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate; (-)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate; (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate); Teavigo; Tea catechin; EGCG
生化機(jī)理(lǐ) 
(-)-Epigallocatechin Gallate (EGCG) is a strong polyphenol catechin antioxidant found in green tea, with broad efficacy against many conditions generated from oxidative damage. Extensive oxidation of low density lipoproteins (LDL) is correlated to cardiovascular diseases, and EGCG is reported to strongly inhibit Cu(2+)-mediated oxidative modification of LDLs. The antiapoptotic proteins Bcl-2 and Bcl-x(L) are observed to suppress apoptosis and convey survival to heavily damaged and mutated cells, and EGCG (along with the other catechins) is shown to directly inhibit these proteins, reestablishing the normal apoptotic pathway in the cell. After treating with EGCG, the expressions of HES1 and Notch2 was obviously inhibited, this indicated that EGCG inhibited colorectal cancer by inhibiting HES1 and Notch2. 
應用(yòng) An inhibitor of Bcl-2 and NOS2