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英(yīng)文名(míng)稱Anti-AIMP3/FITC
中文名稱(chēng):FITC標記的抑癌(ái)蛋(dàn)白(bái)AIMP3抗(kàng)體(tǐ)
別(bié) 名(míng)AIMP 3; AIMP3; Aminoacyl tRNA synthetase complex interacting multifunctional protein 3; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; ARS interacting multifunctional protein 3; Cyclin dependent kinase 6 inhibitor; EEF1E1; Elongation factor p18; Eukaryotic translation elongation factor 1 epsilon 1; Eukaryotic translation elongation factor 1 epsilon-1; Homolog of rat elongation factor p18; MCA3_HUMAN; Multisynthase complex auxiliary component p18; Multisynthetase complex auxiliary component p18; p18; p18 component of aminoacyl tRNA synthetase complex; p18 INK4c; p18 NK6.
規格:100ul
說 明 書100ul
研(yán)究領域(yù)腫(zhǒng)瘤(liú) 細胞生(shēng)物 激酶和磷酸酶
抗(kàng)體(tǐ)來(lái)源Rabbit
克隆(lóng)類(lèi)型(xíng)Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
產(chǎn)品應用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)21kDa
性(xìng) 狀Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human AIMP3/p18
亞 型IgG
純化(huà)方(fāng)法(fǎ)affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹(shào)background:
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Function:
Positive modulator of ATM response to DNA damage.
Subunit:
Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Down-regulated in various cancer tissues.
Similarity:
Contains 1 GST C-terminal domain.
中文名稱(chēng):FITC標記的抑癌(ái)蛋(dàn)白(bái)AIMP3抗(kàng)體(tǐ)
別(bié) 名(míng)AIMP 3; AIMP3; Aminoacyl tRNA synthetase complex interacting multifunctional protein 3; Aminoacyl tRNA synthetase complex-interacting multifunctional protein 3; ARS interacting multifunctional protein 3; Cyclin dependent kinase 6 inhibitor; EEF1E1; Elongation factor p18; Eukaryotic translation elongation factor 1 epsilon 1; Eukaryotic translation elongation factor 1 epsilon-1; Homolog of rat elongation factor p18; MCA3_HUMAN; Multisynthase complex auxiliary component p18; Multisynthetase complex auxiliary component p18; p18; p18 component of aminoacyl tRNA synthetase complex; p18 INK4c; p18 NK6.
詳細介(jiè)紹：
規格:100ul
說 明 書100ul
研(yán)究領域(yù)腫(zhǒng)瘤(liú) 細胞生(shēng)物 激酶和磷酸酶
抗(kàng)體(tǐ)來(lái)源Rabbit
克隆(lóng)類(lèi)型(xíng)Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
產(chǎn)品應用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量(liáng)21kDa
性(xìng) 狀Lyophilized or Liquid
濃(nóng) 度(dù)1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human AIMP3/p18
亞 型IgG
純化(huà)方(fāng)法(fǎ)affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料(liào)：
產品介紹(shào)background:
This gene encodes a multifunctional protein that localizes to both the cytoplasm and nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage, and it plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream MUTED (muted homolog) gene. An EEF1E1-related pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2010]
Function:
Positive modulator of ATM response to DNA damage.
Subunit:
Component of the multisynthase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl and aspartyl-tRNA synthases, and three auxiliary proteins, EEF1E1/p18, AIMP2/p38 and AIMP1/p43. Interacts with ATM and ATR. The interaction with ATM, which takes place independently of TP53, is induced by DNA damage that may occur during genotoxic stress or cell growth. The interaction with ATR is enhanced by UV irradiation
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Down-regulated in various cancer tissues.
Similarity:
Contains 1 GST C-terminal domain.
- 上(shàng)一(yī)條：FITC標(biāo)記(jì)的淋(lín)巴(bā)細胞相關AF4樣(yàng)蛋白抗體(tǐ)
- 下一條(tiáo)：FITC標記的蛋白激(jī)酶A錨(máo)定蛋(dàn)白(bái)6抗(kàng)體(tǐ)
