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FITC標記的整(zhěng)合素樣金(jīn)屬蛋白酶(méi)與凝(níng)血酶(méi)2型抗體
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2017-5-3 瀏覽次數(shù)：1431
英文名(míng)稱Anti-ADAMTS2/FITC
中文(wén)名(míng)稱:FITC標記的整合素(sù)樣(yàng)金屬(shǔ)蛋白酶(méi)與凝血(xiě)酶2型(xíng)抗體(tǐ)
別 名A disintegrin and metalloproteinase with thrombospondin motifs 2; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2; ADAM metallopeptidase with thrombospondin type 1 motif 2; ADAM TS 2; ADAM TS2; ADAM-TS 2; ADAM-TS2; ADAMTS 3; ADAMTS-2; ADAMTS2; ATS2_HUMAN; EC 3.4.24.14; EDS VIIB; EDS VIIC; hPCPNI; NPI; PC I NP; PC I-NP; PCINP; PCPNI; pNPI; Procollagen I N proteinase; Procollagen I N-proteinase; Procollagen I/II amino propeptide processing enzyme; Procollagen I/II amino propeptide-processing enzyme; Procollagen N endopeptidase; Procollagen N-endopeptidase.
規格(gé):100ul
說 明(míng) 書100ul
研究(jiū)領域(yù)腫瘤(liú) 心血(xiě)管(guǎn) 細胞生(shēng)物(wù) 免疫學(xué) 信號轉導(dǎo) 激(jī)酶和磷酸(suān)酶(méi) 細胞(bāo)粘(nián)附分子(zǐ) 細胞(bāo)外基質(zhì) 泛素
抗體(tǐ)來源Rabbit
克隆(lóng)類(lèi)型(xíng)Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
產品應用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子(zǐ) 量108kDa
性 狀Lyophilized or Liquid
濃(nóng) 度1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human ADAMTS2
亞(yà) 型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品(pǐn)介紹(shào)background:
ADAMTS2 is a member of the larger family of ADAMs (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS2 (A Disintegrin And Metalloproteinase with ThromboSpondin-2 motif), also known as Procollagen I N-Proteinase (PNP), was first described in calf skin as a proteinase that processes the amino end of Type-I collagen. PNP expression was found in skin, aorta, liver, tendon, bladder, retina, and skeletal muscle. Later, PNP was found to be a member of a larger family of ADAMs metalloproteinases containing thrombospondin (TS) repeats. Full length human ADAMTS2 contains 1211 amino acids (bovine, 1205 amino acids) and has a predicted mass of 134.7 kDa, but glycosylation and the abundance of cysteine residues gives ADAMTS2 a greater apparent molecular weight on reduced SDS-PAGE gels. Purified ADAMTS2 resolves at a lower molecular weight of 107 kDa, due to cleavage at the furin site. ADAMTS2 contains the canonical HexxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active, cleaving procollagen. In addition to the metalloprotease domain, ADAMTS2 has a propeptide domain, a prohormone convertase (PC, furin) cleavage site, a cysteine-rich domain, and three thrombospondin 1 like domains, followed by a unique C-terminal domain. ADAMTS2 does not have a transmembrane domain, unlike many of the ADAMs proteases, and is a secreted protein, much of which binds to the ECM (extracellular matrix). ADAMTS2 knockout mice develop fragile skin (similar to dermatospaxis), and male infertility. Mutations of the ADAMTS2 gene are responsible for human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis. ADAMTS2 is involved in collagen biosynthesis and may also play role in development and angiogenesis.
中文(wén)名(míng)稱:FITC標記的整合素(sù)樣(yàng)金屬(shǔ)蛋白酶(méi)與凝血(xiě)酶2型(xíng)抗體(tǐ)
別 名A disintegrin and metalloproteinase with thrombospondin motifs 2; A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 2; ADAM metallopeptidase with thrombospondin type 1 motif 2; ADAM TS 2; ADAM TS2; ADAM-TS 2; ADAM-TS2; ADAMTS 3; ADAMTS-2; ADAMTS2; ATS2_HUMAN; EC 3.4.24.14; EDS VIIB; EDS VIIC; hPCPNI; NPI; PC I NP; PC I-NP; PCINP; PCPNI; pNPI; Procollagen I N proteinase; Procollagen I N-proteinase; Procollagen I/II amino propeptide processing enzyme; Procollagen I/II amino propeptide-processing enzyme; Procollagen N endopeptidase; Procollagen N-endopeptidase.
詳細介紹(shào)：
規格(gé):100ul
說 明(míng) 書100ul
研究(jiū)領域(yù)腫瘤(liú) 心血(xiě)管(guǎn) 細胞生(shēng)物(wù) 免疫學(xué) 信號轉導(dǎo) 激(jī)酶和磷酸(suān)酶(méi) 細胞(bāo)粘(nián)附分子(zǐ) 細胞(bāo)外基質(zhì) 泛素
抗體(tǐ)來源Rabbit
克隆(lóng)類(lèi)型(xíng)Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow,
產品應用(yòng)IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子(zǐ) 量108kDa
性 狀Lyophilized or Liquid
濃(nóng) 度1mg/ml
免 疫(yì) 原KLH conjugated synthetic peptide derived from human ADAMTS2
亞(yà) 型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相(xiāng)關(guān)資(zī)料(liào)：
產品(pǐn)介紹(shào)background:
ADAMTS2 is a member of the larger family of ADAMs (A Disintegrin And Metalloproteinase) metalloproteinases containing thrombospondin (TS) repeats. ADAMTS2 (A Disintegrin And Metalloproteinase with ThromboSpondin-2 motif), also known as Procollagen I N-Proteinase (PNP), was first described in calf skin as a proteinase that processes the amino end of Type-I collagen. PNP expression was found in skin, aorta, liver, tendon, bladder, retina, and skeletal muscle. Later, PNP was found to be a member of a larger family of ADAMs metalloproteinases containing thrombospondin (TS) repeats. Full length human ADAMTS2 contains 1211 amino acids (bovine, 1205 amino acids) and has a predicted mass of 134.7 kDa, but glycosylation and the abundance of cysteine residues gives ADAMTS2 a greater apparent molecular weight on reduced SDS-PAGE gels. Purified ADAMTS2 resolves at a lower molecular weight of 107 kDa, due to cleavage at the furin site. ADAMTS2 contains the canonical HexxHxxxxxH zinc metalloproteinase motif, and has been shown to be proteolytically active, cleaving procollagen. In addition to the metalloprotease domain, ADAMTS2 has a propeptide domain, a prohormone convertase (PC, furin) cleavage site, a cysteine-rich domain, and three thrombospondin 1 like domains, followed by a unique C-terminal domain. ADAMTS2 does not have a transmembrane domain, unlike many of the ADAMs proteases, and is a secreted protein, much of which binds to the ECM (extracellular matrix). ADAMTS2 knockout mice develop fragile skin (similar to dermatospaxis), and male infertility. Mutations of the ADAMTS2 gene are responsible for human Ehlers-Danlos syndrome type VII C and bovine dermatosparaxis. ADAMTS2 is involved in collagen biosynthesis and may also play role in development and angiogenesis.
