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標記一抗(kàng)
英文名稱Anti-Apolipoprotein E3/FITC
中文名稱(chēng):FITC標記的(dí)載脂(zhī)蛋白E3抗體(tǐ)
別 名AD2; APOE3; ApoEb; Apolipoprotein EIII; Apolipoprotein E; APOE_HUMAN.
規(guī)格:100ul
說(shuō) 明 書100ul
研究領域腫(zhǒng)瘤 細(xì)胞生物 免疫學(xué) 神經生物學(xué) 信(xìn)號(hào)轉(zhuǎn)導(dǎo) 細胞凋(diāo)亡 轉錄調節因(yīn)子
抗體來(lái)源(yuán)Rabbit
克(kè)隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Pig, Cow,
產品應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
性 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免(miǎn) 疫 原KLH conjugated synthetic peptide derived from human APOE3
亞(yà) 型IgG
純(chún)化方(fāng)法affinity purified by Protein A
儲 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹background:
Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due to increased plasma cholesterol and triglycerides levels which are the consequence of impaired clearance of chylomicron and VLDL remnants.
Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].
中文名稱(chēng):FITC標記的(dí)載脂(zhī)蛋白E3抗體(tǐ)
別 名AD2; APOE3; ApoEb; Apolipoprotein EIII; Apolipoprotein E; APOE_HUMAN.
詳細(xì)介(jiè)紹：
規(guī)格:100ul
說(shuō) 明 書100ul
研究領域腫(zhǒng)瘤 細(xì)胞生物 免疫學(xué) 神經生物學(xué) 信(xìn)號(hào)轉(zhuǎn)導(dǎo) 細胞凋(diāo)亡 轉錄調節因(yīn)子
抗體來(lái)源(yuán)Rabbit
克(kè)隆類型Polyclonal
交叉反應 Human, Mouse, Rat, Pig, Cow,
產品應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
性 狀Lyophilized or Liquid
濃 度(dù)1mg/ml
免(miǎn) 疫 原KLH conjugated synthetic peptide derived from human APOE3
亞(yà) 型IgG
純(chún)化方(fāng)法affinity purified by Protein A
儲 存(cún) 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條(tiáo)件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關資料：
產品介紹background:
Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Compared with E3 and E4, E2 exhibits the lowest receptor binding affinity. Defects in ApoE are a cause of hyperlipoproteinemia type III due to increased plasma cholesterol and triglycerides levels which are the consequence of impaired clearance of chylomicron and VLDL remnants.
Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].
- 上(shàng)一(yī)條(tiáo)：FITC標記的載脂(zhī)蛋(dàn)白C2抗(kàng)體
- 下(xià)一條：FITC標記的(dí)鐵調節蛋白(bái)2抗體
