產(chǎn)品(pǐn)中(zhōng)心
標(biāo)記(jì)一(yī)抗
英(yīng)文(wén)名稱(chēng)Anti-ARA24/FITC
中文名(míng)稱:FITC標(biāo)記(jì)的雄(xióng)激素受體相(xiāng)關(guān)蛋白24抗體(tǐ)
別 名Ran; Androgen receptor associated protein 24; ARA 24; ARA24; Gsp1; GTP binding nuclear protein RAN; GTPase Ran; LPS; RAN member RAS oncogene family; Ras like protein TC4; Ras related nuclear protein; RASL2 8; TC 4; TC4; RAN_HUMAN.
規(guī)格:100ul
說(shuō) 明 書(shū)100ul
研(yán)究(jiū)領(lǐng)域細胞生(shēng)物 免疫學 生長(cháng)因子和激素(sù) 轉(zhuǎn)錄調(tiáo)節(jié)因子 轉運蛋白(bái)
抗體來源(yuán)Rabbit
克隆(lóng)類型(xíng)Polyclonal
交叉(chā)反(fǎn)應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
產品(pǐn)應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子(zǐ) 量(liáng)24kDa
性(xìng) 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫 原(yuán)KLH conjugated synthetic peptide derived from human ARA24
亞 型IgG
純化方法(fǎ)affinity purified by Protein A
儲 存 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存(cún)條件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介(jiè)紹background:
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
中文名(míng)稱:FITC標(biāo)記(jì)的雄(xióng)激素受體相(xiāng)關(guān)蛋白24抗體(tǐ)
別 名Ran; Androgen receptor associated protein 24; ARA 24; ARA24; Gsp1; GTP binding nuclear protein RAN; GTPase Ran; LPS; RAN member RAS oncogene family; Ras like protein TC4; Ras related nuclear protein; RASL2 8; TC 4; TC4; RAN_HUMAN.
詳細(xì)介紹(shào)：
規(guī)格:100ul
說(shuō) 明 書(shū)100ul
研(yán)究(jiū)領(lǐng)域細胞生(shēng)物 免疫學 生長(cháng)因子和激素(sù) 轉(zhuǎn)錄調(tiáo)節(jié)因子 轉運蛋白(bái)
抗體來源(yuán)Rabbit
克隆(lóng)類型(xíng)Polyclonal
交叉(chā)反(fǎn)應(yīng) Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
產品(pǐn)應用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子(zǐ) 量(liáng)24kDa
性(xìng) 狀(zhuàng)Lyophilized or Liquid
濃 度1mg/ml
免(miǎn) 疫 原(yuán)KLH conjugated synthetic peptide derived from human ARA24
亞 型IgG
純化方法(fǎ)affinity purified by Protein A
儲 存 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存(cún)條件(jiàn)Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資料：
產品介(jiè)紹background:
Ran (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The Ran protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of Ran requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in Ran disrupt DNA synthesis. Because of its many functions, it is likely that Ran interacts with several other proteins. Ran regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. Ran could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of Ran-GTP around chromatin which, in turn, induces the local nucleation of microtubules. Ran is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). Ran coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease.
