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一抗(kàng)
英文(wén)名稱(chēng) Anti-phospho-ADAM17 (Thr735)
中文名稱(chēng) 磷酸(suān)化CD156b抗(kàng)體(tǐ)
別 名 ADAM17 (phospho T735); p-ADAM17 (phospho T735); p-CD156b(phospho T735); A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme).
濃 度 1mg/1ml
規(guī) 格 0.2ml/100μg
抗(kàng)體(tǐ)來源 Rabbit
克(kè)隆類(lèi)型 polyclonal
交叉反(fǎn)應 Human, Mouse, Rat, Pig, Cow, Sheep
產(chǎn)品類(lèi)型 一抗 磷酸化抗體(tǐ)
研(yán)究領(lǐng)域(yù) 腫瘤(liú) 細(xì)胞(bāo)生物 神經生物學 信號(hào)轉導(dǎo) 幹細胞(bāo) 轉錄(lù)調節因(yīn)子 新(xīn)陳代(dài)謝
蛋(dàn)白(bái)分子量(liáng) predicted molecular weight: 68kDa
性 狀 Lyophilized or Liquid
免 疫(yì) 原 KLH conjugated synthesised phosphopeptide derived from human ADAM17 around the phosphorylation site of Thr735
亞(yà) 型 IgG
純(chún)化(huà)方(fāng)法(fǎ) affinity purified by Protein A
儲 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品(pǐn)應(yīng)用(yòng) WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切片需(xū)做抗原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品介紹 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].
Function : Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
Subunit : Interacts with MAD2L1, MAPK14 and MUC1.
Subcellular Location : Membrane.
Tissue Specificity : Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Similarity : Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Database links : UniProtKB/Swiss-Prot: P78536.1
中文名稱(chēng) 磷酸(suān)化CD156b抗(kàng)體(tǐ)
別 名 ADAM17 (phospho T735); p-ADAM17 (phospho T735); p-CD156b(phospho T735); A disintegrin and metalloproteinase domain 17; ADAM 17; ADAM metallopeptidase domain 17; ADAM17 protein; CD 156b; CD156b; CD156b antigen; CSVP; MGC71942; Snake venom like protease; TACE; TNF alpha convertase; TNF alpha converting enzyme; Tumor Necrosis Factor Alpha Converting Enzyme; A disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme).
詳(xiáng)細(xì)介(jiè)紹：
濃 度 1mg/1ml
規(guī) 格 0.2ml/100μg
抗(kàng)體(tǐ)來源 Rabbit
克(kè)隆類(lèi)型 polyclonal
交叉反(fǎn)應 Human, Mouse, Rat, Pig, Cow, Sheep
產(chǎn)品類(lèi)型 一抗 磷酸化抗體(tǐ)
研(yán)究領(lǐng)域(yù) 腫瘤(liú) 細(xì)胞(bāo)生物 神經生物學 信號(hào)轉導(dǎo) 幹細胞(bāo) 轉錄(lù)調節因(yīn)子 新(xīn)陳代(dài)謝
蛋(dàn)白(bái)分子量(liáng) predicted molecular weight: 68kDa
性 狀 Lyophilized or Liquid
免 疫(yì) 原 KLH conjugated synthesised phosphopeptide derived from human ADAM17 around the phosphorylation site of Thr735
亞(yà) 型 IgG
純(chún)化(huà)方(fāng)法(fǎ) affinity purified by Protein A
儲 存 液(yè) Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
產(chǎn)品(pǐn)應(yīng)用(yòng) WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石(shí)蠟(là)切片需(xū)做抗原(yuán)修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存(cún)條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
相關資料：
產(chǎn)品介紹 This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq].
Function : Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway (By similarity).
Subunit : Interacts with MAD2L1, MAPK14 and MUC1.
Subcellular Location : Membrane.
Tissue Specificity : Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney.
Similarity : Contains 1 disintegrin domain.
Contains 1 peptidase M12B domain.
Database links : UniProtKB/Swiss-Prot: P78536.1
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