產品(pǐn)中心(xīn)
標記(jì)一(yī)抗
英(yīng)文名稱Anti-Phospho-beta-Arrestin 1 (Ser412)/FITC
中(zhōng)文名稱(chēng):FITC標記的(dí)磷酸化β抑(yì)製(zhì)蛋白1抗(kàng)體
別 名(míng)beta Arrestin 1 (phospho S412); p-beta Arrestin 1 (phospho S412); ARB 1; ARB1; ARR 1; ARR1; ARRB 1; ARRB1; Arrestin beta 1.
規(guī)格(gé):100ul
說(shuō) 明 書100ul
產品(pǐn)類(lèi)型(xíng)磷(lín)酸化抗體(tǐ)
研(yán)究(jiū)領域腫(zhǒng)瘤(liú) 細(xì)胞(bāo)生(shēng)物 免疫(yì)學 信號轉導 轉(zhuǎn)錄調節因(yīn)子(zǐ) 激(jī)酶和(hé)磷(lín)酸(suān)酶 通道蛋白(bái) 細胞(bāo)膜受(shòu)體 糖(táng)尿病 G蛋(dàn)白偶聯受體
抗(kàng)體來源(yuán)Rabbit
克隆類(lèi)型Polyclonal
交(jiāo)叉(chā)反(fǎn)應 Human, Mouse, Rat, Cow,
產品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)45kDa
細胞定位(wèi)細胞(bāo)膜(mó)
性 狀(zhuàng)Lyophilized or Liquid
濃 度(dù)1mg/ml
免(miǎn) 疫(yì) 原(yuán)KLH conjugated Synthesised phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412
亞 型(xíng)IgG
純化(huà)方法affinity purified by Protein A
儲(chǔ) 存 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品(pǐn)介紹background:
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
中(zhōng)文名稱(chēng):FITC標記的(dí)磷酸化β抑(yì)製(zhì)蛋白1抗(kàng)體
別 名(míng)beta Arrestin 1 (phospho S412); p-beta Arrestin 1 (phospho S412); ARB 1; ARB1; ARR 1; ARR1; ARRB 1; ARRB1; Arrestin beta 1.
詳細(xì)介紹(shào)：
規(guī)格(gé):100ul
說(shuō) 明 書100ul
產品(pǐn)類(lèi)型(xíng)磷(lín)酸化抗體(tǐ)
研(yán)究(jiū)領域腫(zhǒng)瘤(liú) 細(xì)胞(bāo)生(shēng)物 免疫(yì)學 信號轉導 轉(zhuǎn)錄調節因(yīn)子(zǐ) 激(jī)酶和(hé)磷(lín)酸(suān)酶 通道蛋白(bái) 細胞(bāo)膜受(shòu)體 糖(táng)尿病 G蛋(dàn)白偶聯受體
抗(kàng)體來源(yuán)Rabbit
克隆類(lèi)型Polyclonal
交(jiāo)叉(chā)反(fǎn)應 Human, Mouse, Rat, Cow,
產品應(yīng)用IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分(fēn) 子 量(liáng)45kDa
細胞定位(wèi)細胞(bāo)膜(mó)
性 狀(zhuàng)Lyophilized or Liquid
濃 度(dù)1mg/ml
免(miǎn) 疫(yì) 原(yuán)KLH conjugated Synthesised phosphopeptide derived from human beta-Arrestin 1 around the phosphorylation site of Ser412
亞 型(xíng)IgG
純化(huà)方法affinity purified by Protein A
儲(chǔ) 存 液(yè)0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保(bǎo)存條件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
相關(guān)資(zī)料(liào)：
產品(pǐn)介紹background:
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
- 上一條(tiáo)：FITC標記(jì)的磷(lín)酸化間變(biàn)型(xíng)淋巴(bā)瘤激(jī)酶(méi)抗體
- 下(xià)一(yī)條(tiáo)：FITC標(biāo)記(jì)的磷酸化有(yǒu)絲分裂(liè)激酶(méi)B/C抗體
